Mangel & Bonsall, 2007

Me parece que este artículo no tiene una aplicación directa a nuestro trabajo, pero aunque está enfocado a medicina regenerativa en general sí que hace algunos comentarios que me han parecido interesantes para tenerlos en cuenta:

The current enthusiasm for regenerative medicine and associated interest in stem cells [...] is based on the assumption that we can remove stem cells from their natural habitat, propagate them in culture, transplant them into a foreign environment and assume that the transplanted cells will do as we wish or that we can manipulate them in vivo with desired results (Fuchs et al. 2004). However, there may be enormous differences between what stem cells do in their original niche and what they can do when put into culture or when transplanted to a new location (Anderson 2001).

We should also develop predictive models for the consequences of potential regenerative therapy. For example, we may ask what will happen when a stem cell with different life history properties is transplanted into a niche with a certain set of signaling properties and feedback controls - which set of stem, amplifying transit and differentiated cells will emerge as a result of the transplantation?

También me ha venido bien que me recordaran los comportamientos básicos de las células madre:

1) Quiescencia
2) División simétrica
3) División asimétrica
4) Apoptosis o migración fuera del nicho