La célula madre espermatogónicas, en el contexto del nicho celular

1. CELULAS MADRE ADULTAS (Mangel´s concepts)

2. NICHO:

• Componentes:

-Generales (No place like home..) (Stem cell niche as an entity of action...)

-Específico (The Niche for Spermatogonial Stem Cells in the Mammalian testis) (Effects of aging and Niche Microenviroments on SSCs Self-Renewal..) (New insights into male gametogenesis:what about the spermatogonial stem cell niche?) (Mechanistic insight...) (The missing niche for Spermatogonial Stem Cells: Do Blood Vessels Point the way?)

• Factores (INPUTS, OUTPUS, INTERACCION GÉNICA...)
• Intro --> Nicho como diana terapéutica

3.El nicho como diana para IDENTIFICACIÓN, AISLAMIENTO y DIFERENCIACION(HOMING)